Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI

Status: Recruiting
Location: See all (4) locations...
Study Type: Observational
SUMMARY

Establish a deep learning model based on multi-parameter magnetic resonance imaging to predict the efficacy of neoadjuvant therapy for locally advanced rectal cancer.This study intends to combine DCE with conventional MRI images for DL, establish a multi-parameter MRI model for predicting the efficacy of CRT, and compare it with the DL and non-artificial quantitative MRI diagnostic model constructed by conventional MRI to evaluate the role of DL in MRI predicting CRT. And this study also tries to build a DL platform to assess the efficacy of LARC neoadjuvant radiotherapy and chemotherapy, accurately assess patients' complete respose (pCR) after CRT, and provide an important basis for guiding clinical decision-making.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Clinical suspicion or colonoscopic pathology of rectal cancer

• Age over 18 years

• Informed consent and signed informed consent form

Locations
Other Locations
China
Sixth Affiliated Hospital, Sun Yat-sen University
RECRUITING
Guangzhou
The First Affiliated Hospital of Jinan University
NOT_YET_RECRUITING
Guangzhou
The Second Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING
Guangzhou
Fifth Affiliated Hospital, Sun Yat-sen University
NOT_YET_RECRUITING
Zhuhai
Contact Information
Primary
Xiaochun Meng
mengxch3@mail.sysu.edu.cn
13719166488
Backup
Peiyi Xie
xiepy6@mail.sysu.edu.cn
13724071514
Time Frame
Start Date: 2022-06-24
Estimated Completion Date: 2027-12
Participants
Target number of participants: 1700
Treatments
complete response
Patients receiving neoadjuvant therapy achieved pathological complete response before LARC.
non complete response
Patients receiving neoadjuvant therapy did not achieve pathological complete response before LARC.
Related Therapeutic Areas
Sponsors
Leads: Sixth Affiliated Hospital, Sun Yat-sen University
Collaborators: Fifth Affiliated Hospital, Sun Yat-Sen University, Second Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of Jinan University

This content was sourced from clinicaltrials.gov