Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI
Status: Recruiting
Location: See all (4) locations...
Study Type: Observational
SUMMARY
Establish a deep learning model based on multi-parameter magnetic resonance imaging to predict the efficacy of neoadjuvant therapy for locally advanced rectal cancer.This study intends to combine DCE with conventional MRI images for DL, establish a multi-parameter MRI model for predicting the efficacy of CRT, and compare it with the DL and non-artificial quantitative MRI diagnostic model constructed by conventional MRI to evaluate the role of DL in MRI predicting CRT. And this study also tries to build a DL platform to assess the efficacy of LARC neoadjuvant radiotherapy and chemotherapy, accurately assess patients' complete respose (pCR) after CRT, and provide an important basis for guiding clinical decision-making.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Clinical suspicion or colonoscopic pathology of rectal cancer
• Age over 18 years
• Informed consent and signed informed consent form
Locations
Other Locations
China
Sixth Affiliated Hospital, Sun Yat-sen University
RECRUITING
Guangzhou
The First Affiliated Hospital of Jinan University
NOT_YET_RECRUITING
Guangzhou
The Second Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING
Guangzhou
Fifth Affiliated Hospital, Sun Yat-sen University
NOT_YET_RECRUITING
Zhuhai
Contact Information
Primary
Xiaochun Meng
mengxch3@mail.sysu.edu.cn
13719166488
Backup
Peiyi Xie
xiepy6@mail.sysu.edu.cn
13724071514
Time Frame
Start Date:2022-06-24
Estimated Completion Date:2027-12
Participants
Target number of participants:1700
Treatments
complete response
Patients receiving neoadjuvant therapy achieved pathological complete response before LARC.
non complete response
Patients receiving neoadjuvant therapy did not achieve pathological complete response before LARC.
Leads: Sixth Affiliated Hospital, Sun Yat-sen University
Collaborators: Fifth Affiliated Hospital, Sun Yat-Sen University, Second Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of Jinan University